William Jorgensen is a graduate of Princeton and Harvard, spent 15 years on the faculty at Purdue, and in 1990 moved to Yale, where he is a Sterling Professor and was recently the Director of the Division of Physical Sciences and Engineering. His research covers both computation and experiment. He has combined quantum, statistical, and molecular mechanics to model chemistry in solution. He has been a leader in computational studies of organic and enzymatic reactions in solution, molecular recognition, protein-ligand binding, and molecular properties. His OPLS force fields and TIPnP water models are widely used. His research group is also actively engaged in de novo drug design and synthesis, particularly for anti-infective, anti-proliferative, and anti-inflammatory agents. Free-energy perturbation calculations are at the heart of the group’s abilities for efficient lead optimization. He received an ACS Cope Scholar Award, the ACS Award for Computers in Chemical and Pharmaceutical Research, the ACS Hildebrand Award, AAAS and ACS Fellowships, the ISQBP Award in Computational Biology, and the Sato International Award from the Pharmaceutical Society of Japan. He has been elected to membership in the International Academy of Quantum Molecular Science, American Academy of Arts & Sciences, and US National Academy of Sciences. Most recently, he received the 2015 Tetrahedron Prize. He has been the Editor of the ACS Journal of Chemical Theory and Computation since its founding in 2005.