Kurt Faber

University of Graz - AT

The driving force of Dr. Faber’s research is the search of biocatalytic methods for (asymmetric) organic synthesis, where traditional (chemical) methodology is lacking, inefficient, or non-selective. Particular research interests are: (1) Enzymatic functionalization of electronically activated alkenes via asymmetric addition of H2O using (CoA-dependent) hydratases. The latter transformation furnishes nonracemic hydroxy-compounds with 100% atom economy. The use of 'minimized' CoA-substrates, such as N-acetylcysteamine derivatives opens the way to preparative-scale applications. (2) Selective activation of hydroxy-compounds derived from renewable resources using enzymatic phosphorylation at the expense of cheap and innocuous inorganic poly- or di-phosphate as phosphate donor. This methodology has the potential to replace inefficient and 'dirty' chemical methodology based on sulfonates and/or Mitsunobu-conditions. (3) Enzymatic carboxylation of aromatics or heteroaromatics to furnish the corresponding aryl-carboxylic acids in a regioselective fashion. Thus, CO2 is being used as a raw material for the production of valuable organic compounds.